理化学研究所（野依良治理事長）は、全身の筋肉まひを引き起こす運動神経変性疾患の1つ「筋萎縮性側索硬化症（ALS）」の運動神経細胞の中に、小児期に発症する運動神経変性疾患「脊髄性筋萎縮症（SMA）」と類似した異常を発見し、2つの疾患に共通する ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms.

Splicing of pre-messenger RNA is regulated differently in the brain compared with other tissues. Recognition of aberrations in splicing events that are associated with neurological disease has ...

A recent collaborative PNAS paper by the Allain (IBC), Jonas (IMBB), Leitner (IMSB) and Sharma groups (University of Arizona) reveals how early spliceosome complexes are brought together via specific ...

In multicellular organisms, the earliest products of transcription, called pre-mRNAs, undergo a molecular makeover before shipping out to the cytoplasm, where the modified mRNAs spell out the recipe ...